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Figure 8 | Molecular Cancer

Figure 8

From: Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

Figure 8

IBP regulates the sensitivity to cisplatin partly through AKT/p53 pathway. (A) In stable MCF-7/IBP-RNAi cells, cells were infected with p53 targeting RNAi lentiviral or control lentiviral, and then treated with increasing cisplatin for 24 h. Cell proliferation rates were measured with CCK-8 assay. (B) Stable IBP-knockdown HCT116 p53−/− cells were treated with cisplatin for 24 h and cell proliferation were measured. (C and D) IBP over-expressing MCF-7 cells were treated with cisplatin and 10 μ mol/L Ly294002 for 24 h. Cell proliferation was measured by CCK-8 assay (C). Cleaved PARP and AKT Ser-473 phosphorylation were detected by western blot (D).

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Molecular Cancer

ISSN: 1476-4598