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Figure 1 | Molecular Cancer

Figure 1

From: Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

Figure 1

Cytotoxic activity of Antp-TPR hybrid peptide to GB cells. (A) Viability of GB cells (U251, A172, and SN19) treated with Antp-TPR peptide. Cells were incubated with Antp-TPR peptide at the indicated concentrations, and analyzed for cell viability as described in the Materials and Methods section. Data represent the mean ± SD from experiments performed in triplicate. (B) Analysis of Hsp90, Hsp70, PTEN, and Akt expression in GB and normal cell lines. Cell extracts from the indicated GB and normal PE (ACBRI 515) cell lines were examined for Hsp90, Hsp70, PTEN, and Akt expression by Western-blot analysis with corresponding antibodies. β-Actin was used as the loading control. Bands were visualized by chemiluminescence as described in the Materials and Methods section.

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