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Table 1 Cancer suppressor or promoter activity of Wnt pathway components and microRNAs involved in urological cancers

From: Wnt signaling pathways in urological cancers: past decades and still growing

Gene Cancer suppressor activity Cancer promoter activity
Wnt components   
β-catenin - 36,68, 71, 123, 140
GSK3-β 12, 36 -
Frizzled receptors - 53, 54, 71
sFRP1 86, 89, 90, 91, 103, 106, 137, 138 110
sFRP2 138 111
sFRP3 - 112
sFRP4 138 -
sFRP5 107, 138 -
WIF1 108, 118, 138, 139, 140 -
DKK1 23 129, 130
DKK2 109 -
DKK3 22, 138 -
DKK4 - 24
Wnt3a - 144
Wnt5a - 116, 119
Wnt7b - 136
Wnt11 - 117
MicroRNAs   
miR-15a 144 -
miR-16a 144 -
miR-200 family 145 -
  1. Numbers indicate references.