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Figure 1 | Molecular Cancer

Figure 1

From: Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non–small-cell lung cancer xenograft models

Figure 1

Expression of VEGFR2 and effect of motesanib on NSCLC tumor cell proliferation in vitro. (A) Relative expression levels of total and phosphorylated human VEGFR2 protein by HUVECs, A549, Calu-6, NCI-H358, NCI-H1650, and NCI-H1299 cells in full-serum media (lane 1), serum-free conditions (lane 2), or serum-free conditions with 50 ng/mL recombinant human VEGF (lane 3). (B) In vitro proliferation of HUVECs, A549, Calu-6, NCI-H358, NCI-H1650, and NCI-H1299 cells in full-serum conditions or (HUVECs only) in serum-free conditions with 50 ng/mL recombinant human VEGF after addition of motesanib (at concentrations of 0.0025 to 5000 nM) or docetaxel (at concentrations of 0.001 to 5000 nM). (C) IC50 curves for in vitro proliferation of each of the cell lines shown in panel B. IC50 = Half-maximal inhibitory concentration.

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Molecular Cancer

ISSN: 1476-4598