Increased expression of miR-146a in the gastrin KO mouse gastric cancer model and human gastric cancer. (A) The relative expression of miR-146a in metaplastic fundic tissue (n = 8) and hyperplastic antral mucosa (n = 4)/antral adenomas (n = 4) from gastrin knockout (KO) mice compared to the average expression in matching wild type (WT) mouse tissue. * = P < 0.05. (B) Waterfall plot of the expression of miR-146a in 37 human gastric adenocarcinomas relative to the expression in adjacent normal tissue. miR-146a was up-regulated in 27 out of 37 tumors (73%). The expression levels of miR-146a were determined by qPCR and normalized to those of the endogenous control RNU44.