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Figure 9 | Molecular Cancer

Figure 9

From: microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Figure 9

Biological processes in gastric cancer cells inhibited by miR-146a. Left panel, miR-146a directly targets IRAK1, CARD10 and COPS8 in SNU638 cells. This leads to inhibition of NF-κB activation and consequently to repressed expression of NF-κB-regulated cytokines and growth factors. Expression of miR-146a is also regulated by NF-κB[16]. Right panel, miR-146a decreases expression of CCL5, CSF-1, IL-8, PDGF and IL-23A, which are involved in monocyte migration and differentiation, proliferation, angiogenesis, lymphangiogenesis and fibroblast and macrophage growth factor release. Thus, miR-146a might act as a tumor suppressor by reducing cancer-promoting effects of NF-κB activity.

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