Figure 8From: EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancerA schematic depiction of the signaling events that regulate the biology of SP cells. Isolated SP cells form metastatic tumors but MP cells do not. Inhibiting EGFR, Src or PI3-kinase significantly impairs the self-renewal properties of SP cells.Back to article page