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Table 1 IC 50 (μmol/L) for P276-00 and roscovitine in Mantle cell lymphoma cell lines

From: P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines

Cell lines P276-00 Roscovitine
48 h 96 h 48 h 96 h
Jeko-1 0.35 ± 0.047 0.21 ± 0.055 25.3 ± 1.83 18 ± 2.82
Mino 0.5 ± 0.28 0.25 ± 0.01 18.1 ± 4.38 14.56 ± 4.55
Rec-1 0.5 ± 0.24 0.33 ± 0.028 32 ± 1.0 40.1 ± 1.27