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Table 1 Immunohistochemical detection of phospho-ERK1/2 expression in invasive breast ductal cancer

From: Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion

Factor

N

p-ERK1/2 positive n (%)

p-ERK1/2 negative n (%)

P value

Total

80

58 (72.5)

22 (27.5)

<0.05

Age

   

>0.05

<50

47

36 (76.6)

11 (23.4)

 

≥50

33

22 (66.7)

11 (33.3)

 

TNM staged

   

<0.05

T1

28

16 (57.14)

12 (42.86)

T1:T2+T3, P<0.05

T2

43

34 (79.07)

9 (20.93)

T3

9

8 (88.89)

1 (11.11)

Tumor size*

   

>0.05

≥3 cm

33

23 (69.7)

10 (30.3)

 

<3 cm

47

35 (74.5)

12 (25.5)

 

Lymph node

   

<0.01

Positive

44

40 (90.9)

4 (9.1)

 

Negative

36

18 (50)

18 (50)

 
  1. * Tumor size was expressed as length × width; tumors with length or width ≥3 cm were classified as >3 cm; tumors with both length and width <3 cm were classified as <3 cm.
  2. Δ Patient with at least one positive lymph node.