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Table 1 Immunohistochemical detection of phospho-ERK1/2 expression in invasive breast ductal cancer

From: Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion

Factor N p-ERK1/2 positive n (%) p-ERK1/2 negative n (%) P value
Total 80 58 (72.5) 22 (27.5) <0.05
Age     >0.05
<50 47 36 (76.6) 11 (23.4)  
≥50 33 22 (66.7) 11 (33.3)  
TNM staged     <0.05
T1 28 16 (57.14) 12 (42.86) T1:T2+T3, P<0.05
T2 43 34 (79.07) 9 (20.93)
T3 9 8 (88.89) 1 (11.11)
Tumor size*     >0.05
≥3 cm 33 23 (69.7) 10 (30.3)  
<3 cm 47 35 (74.5) 12 (25.5)  
Lymph node     <0.01
Positive 44 40 (90.9) 4 (9.1)  
Negative 36 18 (50) 18 (50)  
  1. * Tumor size was expressed as length × width; tumors with length or width ≥3 cm were classified as >3 cm; tumors with both length and width <3 cm were classified as <3 cm.
  2. Δ Patient with at least one positive lymph node.