Figure 4From: Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependenceEstrogen stimulation of HIF-1α and VEGF is PI3K dependent. Western blots of TG1-1 whole cell lysates grown under starvation conditions show an estrogen dependent increase in PI3K (A) which is abrogated by Fulvestrant (ICI). The PI3K inhibitor Wortmannin prevented estradiol stimulated up regulation of HIF-1α (B) and VEGF (C).Back to article page