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Figure 5 | Molecular Cancer

Figure 5

From: Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependence

Figure 5

Hypoxia and estrogen increase human umbilical vein endothelial cell (HUVEC) migration in a HIF-1α dependent manner. Culture medium from TG1-1 cells grown under hypoxic conditions was observed to increase HUVEC migration (A). Further, culture media from cells treated with estradiol significantly enhanced migration (A,B) when compared to non-estradiol supplemented TG1-1 culture media, which was abrogated by YC1. * P < .001 when compared to control.

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