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Figure 7 | Molecular Cancer

Figure 7

From: Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis

Figure 7

Activated ERK1/2 correlates with Mcl-1 expression in HGSOC samples. A TMA containing samples from 120 HGSOC was stained by immunohistochemistry with antibodies specific for phospho-ERK1/2 and Mcl-1. Tumors were scored using the H-score method. (A) Representative images of immunoperoxidase-stained tissue for phospho-ERK1/2 and Mcl-1 demonstrating either negative staining (0), low intensity (1) or high intensity staining (3). (B) Correlation chart for Mcl-1 and ERK between their H-scores as determined by immunohistochemistry. (C) H-score for phospho-ERK1/2 separated into two groups based on the median Mcl-1 H-score of 62.5.

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Molecular Cancer

ISSN: 1476-4598