Anti-tumor activity of Ad315-E1A in HCT-8 xenograft models. (a) Average volume of subcutaneous tumors after receiving various treatments. Values represent the means ± SD for eight mice per group. Statistical differences were evaluated by one-way analysis of variance. **p < 0.01 vs. tumor volume of the Ad315-EGFP group. (b) Percentage of mouse survival analyzed by the Kaplan-Meier method.