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Table 1 Associations of the clinical characteristics and IGFBP3 methylation status in 36 pediatric patients with hepatoblastoma

From: IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

   IGFBP3
parameters group no. of tumors methylated unmethylated P
gendera m 18 3 15 0.2482
  f 18 6 12  
age at diagnosisb < 2 21 4 17 0.3570
  > 2 12 4 8  
histological subtypec f 20 3 17 0.1213
  e 16 6 10  
metastases yes 15 7 8 0.0047
  no 19 1 18  
outcomed NED 25 4 21 0.0508
  DOD 8 4 4  
multifocal growth yes 7 3 4 0.2662
  no 19 4 15  
invasion of large hepatic veins yes 8 6 2 0.0001
  no 25 2 23  
  1. am, male; f, female
  2. bThe age of patients at diagnosis is given in months
  3. cEpithelial component with predominantly fetal, f, or embryonal, e, differentiation
  4. dNED, no evidence of disease; DOD, dead of disease