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Table 1 Tumor multiplicities/incidences in NNK or saline-treated A-C/EBP- or A-C/EBP+ mice fed Dox or regular diet and analyzed at 52 weeks post-NNK/saline administration

From: Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

Group Genotype (A-C/EBP Treatment Diet No. of mice Body weight Gross tumor   Histological lesions   Tumor incidence
  + or -a)    examined (g) per mouse Alveolar hyperplasia per mouse Adenoma per mouse Carcinoma per mouse Adenoma and carcinoma per mouse (%)b
1 - NNK Dox 45 46.2±0.8d,e 1.00 0.11g 1.20h 0.044 1.20h 76 (34)c
2 + NNK Dox 30 43.7±0.8e 1.20 0.23 1.30h 0.13 1.40h 83 (25)
3 - Saline Dox 24 43.7±1.1 0.29 0.08 0.21 0 0.21 21 (5)
4 + Saline Dox 23 43.4±0.8f 0.26 0.17 0.17 0 0.17 13 (3)
5 - NNK Regular 44 39.8±0.8 1.00 0.36 1.30h 0 1.30h 71 (31)i
6 + NNK Regular 40 38.4±0.9 1.00 0.30 1.50h 0.025 1.60h 88 (35)
7 - Saline Regular 38 40.8±1.2 0.27 0.18 0.32 0 0.32 26 (10)
8 + Saline Regular 31 39.9±0.9 0.26 0.19 0.26 0 0.26 19 (6)
  1. aA-C/EBP- is considered as wild-type control.
  2. bPercentage of mice with adenomas or carcinomas.
  3. cNumbers in parentheses show the number of mice having tumors.
  4. dSignificantly different from their respective A-C/EBP+ group (group 1 vs. 2) at P<0.05 by student t-test.
  5. eSignificantly different from their respective regular diet group (group 1 vs. 5, and 2 vs. 6) at P<0.00001 by student t-test.
  6. fSignificantly different from their respective regular diet group (group 4 vs. 8) at P<0.01 by student t-test.
  7. gSignificantly different from their respective regular diet group (group 1 vs. 5) at P<0.05 by student t-test.
  8. hSignificantly different from their respective saline group (group 1 vs. 3, 2 vs. 4, 5 vs. 7, and 6 vs. 8) at P<0.0001 by student t-test.
  9. iSignificantly different from their respective A-C/EBP+ group (group 5 vs. 6) at P=0.0497 by Fisher’s exact test.