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Table 2 Tumor multiplicities/incidences in NNK-treated A-C/EBP- or A-C/EBP+ mice fed Dox or regular diet at 52 weeks post-NNK administration for additional 10 weeks and analyzed at 62 weeks post-NNK administration

From: Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

Group Genotype (A-C/EBP Treatment Diet during No. of mice Body weight Gross tumor   Histological lesions   Tumor incidence
  + or -a)   52-62 weeks examined (g) per mouse Alveolar hyperplasia per mouse Adenoma per mouse Carcinoma per mouse Adenoma and carcinoma per mouse (%)b
1 - NNK Dox 19 42.2±1.4d 2.00 0.37 1.63 0.37e 2.00 95 (17)c
2 + NNK Dox 18 44.5±1.5d 2.83 0.33 2.06 0.056f 2.11 83 (15)
3 - NNK Regular 18 36.2±1.6 1.89 0.11 1.50 0.44 1.94 94 (16)
4 + NNK Regular 18 38.1±1.6 2.22 0.17 2.00 0.44 2.44 78 (14)
  1. aA-C/EBP- is considered as wild-type control.
  2. bPercentage of mice with adenomas or carcinomas.
  3. cNumbers in parentheses show the number of mice having tumors.
  4. dSignificantly different from their respective regular diet group (group 1 vs. 3, 2 vs. 4) at P<0.01 by student t-test.
  5. eSignificantly different from their respective A-C/EBP+ group (group 1 vs. 2) at P<0.05 by student t-test.
  6. fSignificantly different from their respective regular diet group (group 2 vs. 4) at P<0.05 by student t-test.