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Table 2 RBFOX1 mutations and single nucleotide polymorphisms found in CRC cell lines and patient tumour samples

From: Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

 

Mutations

Known SNPs

Cell Lines

CoCM1

c.776C>T; p.Ser259Phe

 

HCT15

c.288C>T; p.Ser96Ser

 

LIM2405

 

c.393A>G; p.Glu131Glu (rs140174146)

LIM2551

c.154delC

 

LOVO

1. c.293C>T; p.Ala98Val

 
 

2. c.353C>T; p.Thr118Met

 

LS411

c.293C>T; p.Ala98Val

 

Patient Samples

33

1. c.851C>T; p.Ala284Val

 
 

2. c.1023G>A;

 
 

p.Gln341Gln

 

53

c.350C>T; p.Pro117Leu*

 

93

c.598G>A; p.Val200Met

 
  1. *Mutation from patient 53 is identical to known SNP rs139251660, but was present only in tumour but not in the paired normal tissue.
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Molecular Cancer

ISSN: 1476-4598