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Table 2 Comparison in gene expression level between p53 mutant and wild-type tumors

From: Expression profiling of ion channel genes predicts clinical outcome in breast cancer

Gene symbol

Gene title

Fold changea

Adjusted

P-valueb

ANO1

anoctamin 1, calcium activated chloride channel

0.66

0.001

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

0.32

< 0.001

CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1

0.79

0.002

CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

0.47

< 0.001

CLCA2

chloride channel accessory 2

2.53

0.039

CLIC5

chloride intracellular channel 5

0.77

< 0.001

CLIC6

chloride intracellular channel 6

0.28

< 0.001

GLRB

glycine receptor, beta

0.32

< 0.001

KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

0.46

< 0.001

KCNE3

potassium voltage-gated channel, Isk-related family, member 3

1.34

< 0.001

KCNE4

potassium voltage-gated channel, Isk-related family, member 4

0.25

< 0.001

KCNJ3

potassium inwardly-rectifying channel, subfamily J, member 3

0.51

< 0.001

KCNK1

potassium channel, subfamily K, member 1

1.44

< 0.001

KCNK6

potassium channel, subfamily K, member 6

0.80

0.010

KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

0.65

< 0.001

KCNN4

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

1.69

< 0.001

MCOLN2

mucolipin 2

1.60

< 0.001

P2RX4

purinergic receptor P2X, ligand-gated ion channel, 4

0.73

< 0.001

SCN7A

sodium channel, voltage-gated, type VII, alpha subunit

0.29

< 0.001

SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

0.71

< 0.001

TPCN1

two pore segment channel 1

0.77

< 0.001

TRPC1

transient receptor potential cation channel, subfamily C, member 1

0.72

0.005

  1. aFold change is calculated by dividing the mean expression of p53 mutant tumor by the mean expression of p53 wild-type tumor.
  2. bP-value is calculated by two-tailed t-test and adjusted by Benjamini & Hochberg correction.
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Molecular Cancer

ISSN: 1476-4598