Skip to main content

Table 2 Comparison in gene expression level between p53 mutant and wild-type tumors

From: Expression profiling of ion channel genes predicts clinical outcome in breast cancer

Gene symbol Gene title Fold changea Adjusted
P-valueb
ANO1 anoctamin 1, calcium activated chloride channel 0.66 0.001
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.32 < 0.001
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.79 0.002
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.47 < 0.001
CLCA2 chloride channel accessory 2 2.53 0.039
CLIC5 chloride intracellular channel 5 0.77 < 0.001
CLIC6 chloride intracellular channel 6 0.28 < 0.001
GLRB glycine receptor, beta 0.32 < 0.001
KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.46 < 0.001
KCNE3 potassium voltage-gated channel, Isk-related family, member 3 1.34 < 0.001
KCNE4 potassium voltage-gated channel, Isk-related family, member 4 0.25 < 0.001
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.51 < 0.001
KCNK1 potassium channel, subfamily K, member 1 1.44 < 0.001
KCNK6 potassium channel, subfamily K, member 6 0.80 0.010
KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.65 < 0.001
KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 1.69 < 0.001
MCOLN2 mucolipin 2 1.60 < 0.001
P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 0.73 < 0.001
SCN7A sodium channel, voltage-gated, type VII, alpha subunit 0.29 < 0.001
SCNN1A sodium channel, non-voltage-gated 1 alpha subunit 0.71 < 0.001
TPCN1 two pore segment channel 1 0.77 < 0.001
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.72 0.005
  1. aFold change is calculated by dividing the mean expression of p53 mutant tumor by the mean expression of p53 wild-type tumor.
  2. bP-value is calculated by two-tailed t-test and adjusted by Benjamini & Hochberg correction.