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Table 4 Correlation between gene expression and histological tumor grade

From: Expression profiling of ion channel genes predicts clinical outcome in breast cancer

Gene symbol Gene title ρa Adjusted
P-valueb
ANO1 anoctamin 1, calcium activated chloride channel -0.23 < 0.001
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.42 < 0.001
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.28 < 0.001
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.30 < 0.001
CLIC1 chloride intracellular channel 1 0.26 < 0.001
CLIC4 chloride intracellular channel 4 0.16 0.022
CLIC5 chloride intracellular channel 5 -0.22 0.001
CLIC6 chloride intracellular channel 6 -0.33 < 0.001
GLRB glycine receptor, beta -0.35 < 0.001
KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.15 0.023
KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 -0.39 < 0.001
KCNE3 potassium voltage-gated channel, Isk-related family, member 3 0.23 < 0.001
KCNE4 potassium voltage-gated channel, Isk-related family, member 4 -0.38 < 0.001
KCNK1 potassium channel, subfamily K, member 1 0.25 < 0.001
KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 -0.30 < 0.001
KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 0.23 < 0.001
MCOLN2 mucolipin 2 0.25 < 0.001
P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 -0.24 < 0.001
PKD1 polycystic kidney disease 1 (autosomal dominant) -0.17 0.012
PKD2 polycystic kidney disease 2 (autosomal dominant) -0.19 0.004
SCN1B sodium channel, voltage-gated, type I, beta subunit -0.27 < 0.001
SCN7A sodium channel, voltage-gated, type VII, alpha subunit -0.41 < 0.001
SCNN1A sodium channel, non-voltage-gated 1 alpha subunit -0.18 0.008
TPCN1 two pore segment channel 1 -0.26 < 0.001
TPCN2 two pore segment channel 2 0.17 0.013
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.25 < 0.001
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -0.21 0.002
VDAC1 voltage-dependent anion channel 1 0.21 0.002
VDAC2 voltage-dependent anion channel 2 0.22 0.001
VDAC3 voltage-dependent anion channel 3 0.26 < 0.001
  1. aρ is the Spearman’s rank correlation coefficient.
  2. bP-value is calculated by Spearman’s rank correlation test and adjusted by Benjamini & Hochberg correction.