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Table 4 Correlation between gene expression and histological tumor grade

From: Expression profiling of ion channel genes predicts clinical outcome in breast cancer

Gene symbol

Gene title

ρa

Adjusted

P-valueb

ANO1

anoctamin 1, calcium activated chloride channel

-0.23

< 0.001

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

-0.42

< 0.001

CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1

-0.28

< 0.001

CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

-0.30

< 0.001

CLIC1

chloride intracellular channel 1

0.26

< 0.001

CLIC4

chloride intracellular channel 4

0.16

0.022

CLIC5

chloride intracellular channel 5

-0.22

0.001

CLIC6

chloride intracellular channel 6

-0.33

< 0.001

GLRB

glycine receptor, beta

-0.35

< 0.001

KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

0.15

0.023

KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

-0.39

< 0.001

KCNE3

potassium voltage-gated channel, Isk-related family, member 3

0.23

< 0.001

KCNE4

potassium voltage-gated channel, Isk-related family, member 4

-0.38

< 0.001

KCNK1

potassium channel, subfamily K, member 1

0.25

< 0.001

KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

-0.30

< 0.001

KCNN4

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

0.23

< 0.001

MCOLN2

mucolipin 2

0.25

< 0.001

P2RX4

purinergic receptor P2X, ligand-gated ion channel, 4

-0.24

< 0.001

PKD1

polycystic kidney disease 1 (autosomal dominant)

-0.17

0.012

PKD2

polycystic kidney disease 2 (autosomal dominant)

-0.19

0.004

SCN1B

sodium channel, voltage-gated, type I, beta subunit

-0.27

< 0.001

SCN7A

sodium channel, voltage-gated, type VII, alpha subunit

-0.41

< 0.001

SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

-0.18

0.008

TPCN1

two pore segment channel 1

-0.26

< 0.001

TPCN2

two pore segment channel 2

0.17

0.013

TRPC1

transient receptor potential cation channel, subfamily C, member 1

-0.25

< 0.001

TRPM4

transient receptor potential cation channel, subfamily M, member 4

-0.21

0.002

VDAC1

voltage-dependent anion channel 1

0.21

0.002

VDAC2

voltage-dependent anion channel 2

0.22

0.001

VDAC3

voltage-dependent anion channel 3

0.26

< 0.001

  1. aρ is the Spearman’s rank correlation coefficient.
  2. bP-value is calculated by Spearman’s rank correlation test and adjusted by Benjamini & Hochberg correction.
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Molecular Cancer

ISSN: 1476-4598