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Figure 3 | Molecular Cancer

Figure 3

From: Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1

Figure 3

AEG-1 knockdown compromises tumorigenecity (n = 6) and pulmonary metastasis (n = 10) of SAS and FaDu cells. (A) time-course plot of tumor volumes. (B) tumor weights at the end-point. All data were expressed as mean ± SEM. *, p < 0.05; **, p < 0.01. (C) microscopy images of xenograft tumors at the end-point. Note the infiltrated invasion fronts in the SCt and FCt groups and the expansile tumor borders in the SB and FB groups. Arrow, focus of perineural invasion. Upper row, H&E stain; lower row, immunohistochemical stain with Lyric 4–7. Scale bar, 100 μm. (D) In vivo lung metastasis assay. Arrow, metastatic focus. Upper row, H&E stain; lower row, immunohistochemical stain with anti- AEG-1 antibody. Scale bar, 500 μm.

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Molecular Cancer

ISSN: 1476-4598