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Figure 5 | Molecular Cancer

Figure 5

From: Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1

Figure 5

AEG-1 knockdown suppressed phosphorylation of serine 536 of the p65 subunit (RelA) of NF-κB. (A) Western blot of total p65 and phosphorylated p65 (serine 536). Data were normalized to respective controls and are were expressed as mean ± SEM; n = 3. NS, not significant (p > 0.05); *, p < 0.05; **, p < 0.01. (B and C) immunohistochemical staining of phosphorylated p65 (Ser536) and MMP1 in formalin-fixed, paraffin embedded OSCC specimens. Expression of phosphorylated p65 and MMP1 was positively cor related with that of AEG-1 both intratumorally (B) and intertumorally (C). Scale bar: 40 ×, 300 μm; 200 ×, 45 μm.

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Molecular Cancer

ISSN: 1476-4598