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Figure 4 | Molecular Cancer

Figure 4

From: LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

Figure 4

Effect of LBH589 on cell cycle proteins and cell cycle progression. (A) Cell cycle analysis in LBH589 treated HCC cells showing arrest in G1 phase. The results represent means ± SD of experiments performed in triplicate. ***P < 0.001, LBH589 treated versus control group. (B) A representative example of cell cycle arrest of HepG2 cell line treated with 50 nM of LBH589 at 48 h. (C) LBH589 induces expression of p16 and p27 and reduces expression of cyclin D1 and cyclin E. β-actin was used as the internal control. All assays were done in triplicate. (D) Gankyrin overexpression attenuated the LBH589-induced G0/G1 phase arrest of HCC cells. ***P < 0.001, the results represent means ± SD of experiments performed in triplicate. (E) A representative example of cell cycle arrest of HepG2 cell line (which transfected human gankyrin/control plasmid) treated with 50 nM of LBH589 at 48 h.

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Molecular Cancer

ISSN: 1476-4598