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Table 1 EV-mediated transfer of proteins via Kinexus phospho-protein microarray analysis in DU145 cells co-cultured with PrEC EVs

From: Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure

Target protein name

Z-ratio (DuP, Du)

PKCz

1.42

SOCS3

1.30

PKCm (PKD)

1.05

KAP

1.05

STAT5A

1.04

Cyclin G1

1.00

IKKa

−1.01

p38g MAPK (Erk6)

−1.02

CK1g

−1.03

MEK5 (MAP2K5)

−1.08

CDK1 (CDC2)

−1.09

STAT6

−1.09

IKKa

−1.14

RIPK1

−1.25

STAT3

−1.48

PAK3

−1.52

RSK1

−3.43

  1. Extracellular vesicles were isolated from PrECs after 7 days in culture as described. PrEC EVs were then co-cultured with DU145 cells for 7 days after which cells were harvested and the harvested cell pellet sent to Kinexus Corporation, Vancouver, BC for analysis. As a control, a sample with DU145 cells co-cultured with DU145 EVs was also generated. These are a portion the results of the array analysis indicating the fold change in protein expression (Z score) of DU145 cells co-cultured with PrEC EVs when compared to DU145 cells co-cultured with DU145 EVs.
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Molecular Cancer

ISSN: 1476-4598