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Figure 3 | Molecular Cancer

Figure 3

From: Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

Figure 3

PTX administration into tumors growing in SCID mice. (A) PTX untreated tumor presenting consistent and extremely dense tumor mass. (B) 9 days after beginning of the experiment a loss of tumor mass was already visible. The periphery of tumor necrosis appears to be sharply delineated with loose tumor cell- and lymphoid cell aggregates. (C) After 15 days tumor destruction has further progressed, associated with diffuse lymphoid infiltrate. (D) The entire tumor inside has been destructed and only the rim of the tumor remained after 24 days. The inside of the tumor is presented by dense collagen fibers with singly scattered lymphoid aggregates. Representative examples of tumor sections from control and PTX-treated group are shown. Scale bars, 2 mm (left), 1 mm (middle), 100 μm (right).

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Molecular Cancer

ISSN: 1476-4598