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Table 1 Analysis of the tumorigenic effect of PTX after sc administration in SCID mice

From: Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

SCID mice Single dose of PTX (ng)* Frequency of PTX injection Observation time (months) Tumor development
1 0.5 5 8 no
2 0.5 5 8 no
3 0.5 5 8 no
4 0.5 5 8 no
5 0.5 5 8 no
6 0.5 5 8 no
7 0.5 5 8 no
8 0.5 5 4** no
  1. *A dose of 0.5ng has been estimated as a concentration at which cell viability still remains.
  2. ** One mouse died during the time of observation for unknown reasons.