Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

Table 1 Analysis of the tumorigenic effect of PTX after sc administration in SCID mice

SCID mice	Single dose of PTX (ng)*	Frequency of PTX injection	Observation time (months)	Tumor development
1	0.5	5	8	no
2	0.5	5	8	no
3	0.5	5	8	no
4	0.5	5	8	no
5	0.5	5	8	no
6	0.5	5	8	no
7	0.5	5	8	no
8	0.5	5	4**	no

*A dose of 0.5ng has been estimated as a concentration at which cell viability still remains.
** One mouse died during the time of observation for unknown reasons.

ISSN: 1476-4598

SCID mice	Single dose of PTX (ng)*	Frequency of PTX injection	Observation time (months)	Tumor development
1	0.5	5	8	no
2	0.5	5	8	no
3	0.5	5	8	no
4	0.5	5	8	no
5	0.5	5	8	no
6	0.5	5	8	no
7	0.5	5	8	no
8	0.5	5	4**	no

SCID mice	Single dose of PTX (ng)*	Frequency of PTX injection	Observation time (months)	Tumor development
1	0.5	5	8	no
2	0.5	5	8	no
3	0.5	5	8	no
4	0.5	5	8	no
5	0.5	5	8	no
6	0.5	5	8	no
7	0.5	5	8	no
8	0.5	5	4**	no

SCID mice	Single dose of PTX (ng)*	Frequency of PTX injection	Observation time (months)	Tumor development
1	0.5	5	8	no
2	0.5	5	8	no
3	0.5	5	8	no
4	0.5	5	8	no
5	0.5	5	8	no
6	0.5	5	8	no
7	0.5	5	8	no
8	0.5	5	4**	no