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Table 2 Effect of PTX administered into tumors growing in SCID mice

From: Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

SCID mice Dose of PTX (ng/kg)* Number of doses Percentage of tumor remission**
1 83 9 100
2 83 9 100
3 68 9 30
4 75 9 100
5 75 9 100
6 75 9 100
7 75 9 30
8 68 9 100
  1. * Each tumor has been treated with 1.5 ng PTX dissolved in 20 μl PBS. Due to different body weight of the mice (18–22 grams) the doses varied from 68 ng/kg to 83 ng/kg.
  2. ** One hundred percent tumor remission was defined as the stage at which the entire tumor inside had been destroyed and only the rim of the tumor remained.