Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity

Table 2 Effect of PTX administered into tumors growing in SCID mice

SCID mice	Dose of PTX (ng/kg)*	Number of doses	Percentage of tumor remission**
1	83	9	100
2	83	9	100
3	68	9	30
4	75	9	100
5	75	9	100
6	75	9	100
7	75	9	30
8	68	9	100

* Each tumor has been treated with 1.5 ng PTX dissolved in 20 μl PBS. Due to different body weight of the mice (18–22 grams) the doses varied from 68 ng/kg to 83 ng/kg.
** One hundred percent tumor remission was defined as the stage at which the entire tumor inside had been destroyed and only the rim of the tumor remained.

ISSN: 1476-4598