Targeted therapy against EGFR and VEGFR using ZD6474 enhances the therapeutic potential of UV-B phototherapy in breast cancer cells

Table 1 ZD6474 potentiates UV-B action on breast cancer cells

Cell line	Treatment regimen	IC₅₀(J/m²)	PF^a
MCF-7	UV-B	101.20 ± 3.86
MCF-7	UV-B + ZD6474	59.20 ± 2.45	1.71
ZR-75-1	UV-B	74.21 ± 4.01
ZR-75-1	UV-B + ZD6474	41.26 ± 3.01	1.80
MDA-MB-468	UV-B	32.54 ± 2.67
MDA-MB-468	UV-B + ZD6474	12.17 ± 2.49	2.67
MDA-MB-231	UV-B	35.33 ± 1.23
MDA-MB-231	UV-B + ZD6474	15.12 ± 2.12	2.34
T-47D	UV-B	42.12 ± 2.12
T-47D	UV-B + ZD6474	25.21 ± 2.12	1.67
HMEpC	UV-B	250.72 ± 9.12
	UV-B + ZD6474	248.12	1.01

^aPotentiation Factor (PF) indicates a quantitative measure of fold-sensitivity of UV-B radiation treated with 1 μM ZD6474 at a given effect compared with the sensitivity of UV-B alone.

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