miR-451 suppresses NPC xenograft tumor growth in vivo. (A) SUNE-1 cells stably overexpressing miR-451 or scrambled miRNA was subcutaneously injected into nude mice. Four weeks later, SUNE-1 cells stably overexpressing miR-451 had smaller tumors than controls. (B) The growth curves of tumor volumes. (C) Representative picture of tumors formed. (D) Tumor weight. Data is presented as the mean ± SD. *, P < 0.01 compared with control using the Student’s t-test.