Figure 4
From: Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer
Knockdown of uc.106+ alters expression of cell proliferation, motility, and inflammatory genes in LNCaP cells. (A) Knockdown of uc.106+ in LNCaP cells at 24 hr after transfection with siRNA targeting uc.106+ (or scrambled siRNA as control). * P < 0.05 (versus control). (B) Pathway analysis with the 200 top-ranked genes which were significantly up- or down-regulated after siRNA transfection across 3 independent experiments. The analysis shows significant clustering of these genes in several biological processes including cell proliferation and movement, and inflammation.