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Table 2 ucRNA expression changes in LNCaP cells in response to treatment with epigenetic drugs

From: Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer

 

Fold Change*,†

   

ucRNA

5-AzaC

TSA

5-AzaC + TSA

Type‡, host gene, host strand

Overlap with mRNA

Antisense to mRNA

uc.308 + A

3.02

4.66

4.03

n, BTRC, sense

Yes

Yes

uc.434 + A

2.25

3.84

3.59

n, SKOR2, sense

Yes

 

uc.241 + A

2.03

2.31

3.12

n, no gene

No

 

uc.283 + A

1.90

2.17

2.39

n, no gene

No

 

uc.285+

1.82

2.14

2.37

e, CCAR1, sense

Yes

 

uc.85+

1.63

2.03

1.96

n, no gene

No

 
  1. * Fold change: reference are the untreated cells (solvent only); †Cutoff for inclusion: P value (t-test) < 0.01 treatment versus control; ‡ Type is based on UCSC human genome data, UCSC version hg19, NCBI build 37 coordinates, where, n = nonexonic and e = exonic.
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