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Figure 4 | Molecular Cancer

Figure 4

From: miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression

Figure 4

Correlation of miR-125b and EPOR with metastasis and ERBB2. A) Expression of miR-125b (normalized on RNU6 and log2 transformed) in not metastatic (NM), locally recurrent (local) and metastatic (M) breast cancer, detected by RT-qPCR. A significant two-tailed Mann Whitney test) down-regulation in metastatic BC can be observed. B) MiR-125b levels are significantly (p = 0.048, two-tailed Mann Whitney test) down-regulated in ERBB2 strongly positive breast cancers (IHC positive cells > 50%) C) and display an inverse correlation (Spearman r = 0.31, p = 0.04). D) Microarray data from 69 breast cancer without HER-2 amplification shows a highly concordant expression (Spearman r = 0.54, p < 0.0001) of ERBB2/HER2 and EPOR levels.

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Molecular Cancer

ISSN: 1476-4598