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Table 1 Pathways significantly enriched in the list of genes down-regulated by miR-125b and with a MRE in 3'UTR (source: GeneGO Metacore)

From: miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression

# Maps pValue Ratio
1 Immune response_CD28 signaling 2.304E-04 5 54
2 Development_EPO-induced PI3K/AKT pathway and Ca(2+) influx 9.912E-04 4 43
3 Neurophysiological process_Melatonin signaling 9.912E-04 4 43
4 Development_A2A receptor signaling 9.912E-04 4 43
5 Development_EPO-induced MAPK pathway 1.178E-03 4 45
6 Development_WNT5A signaling 1.280E-03 4 46
7 Neurophysiological process_NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons 1.417E-03 5 80
8 Nicotine signaling in dopaminergic neurons, Pt. 1 - cell body 1.502E-03 4 48
9 Development_A2B receptor: action via G-protein alpha s 1.750E-03 4 50
10 Signal transduction_PKA signaling 1.884E-03 4 51
11 Immune response_HSP60 and HSP70/ TLR signaling pathway 2.329E-03 4 54
12 Cell adhesion_Gap junctions 3.608E-03 3 30
13 Development_EGFR signaling pathway 4.086E-03 4 63
14 Oxidative stress_Role of ASK1 under oxidative stress 5.161E-03 3 34
15 Reproduction_GnRH signaling 6.576E-03 4 72
16 Development_Mu-type opioid receptor signaling 7.062E-03 3 38
17 Signal transduction_cAMP signaling 7.062E-03 3 38
18 Transcription_P53 signaling pathway 7.594E-03 3 39
19 Development_PACAP signaling in neural cells 7.594E-03 3 39
20 Apoptosis and survival_Lymphotoxin-beta receptor signaling 9.328E-03 3 42
21 Nicotine signaling in dopaminergic neurons, Pt. 2 - axon terminal 9.953E-03 3 43
22 Development_S1P1 signaling pathway 1.060E-02 3 44
23 Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling 1.128E-02 3 45
24 Transcription_Androgen Receptor nuclear signaling 1.128E-02 3 45
25 Development_Thrombopoietin-regulated cell processes 1.128E-02 3 45
26 Development_GDNF family signaling 1.197E-02 3 46
27 Neurophysiological process_Dopamine D2 receptor signaling in CNS 1.269E-02 3 47
28 Development_TGF-beta-dependent induction of EMT via MAPK 1.269E-02 3 47
29 Development_HGF signaling pathway 1.269E-02 3 47
30 Immune response_Histamine H1 receptor signaling in immune response 1.344E-02 3 48
31 Immune response_Lectin induced complement pathway 1.421E-02 3 49
32 Development_A3 receptor signaling 1.421E-02 3 49
33 Immune response_Histamine signaling in dendritic cells 1.501E-02 3 50
34 Mucin expression in CF via TLRs, EGFR signaling pathways 1.501E-02 3 50
35 Immune response_NFAT in immune response 1.583E-02 3 51
36 Development_IGF-1 receptor signaling 1.667E-02 3 52
37 Signal transduction_Activation of PKC via G-Protein coupled receptor 1.667E-02 3 52
38 Cell adhesion_ECM remodeling 1.667E-02 3 52
39 Immune response_Classical complement pathway 1.667E-02 3 52
40 Development_Endothelin-1/EDNRA signaling 1.754E-02 3 53
41 Membrane-bound ESR1: interaction with G-proteins signaling 1.844E-02 3 54
42 Development_FGFR signaling pathway 1.844E-02 3 54
43 Immune response_Fc epsilon RI pathway 1.936E-02 3 55
44 Regulation of lipid metabolism_Insulin regulation of glycogen metabolism 2.030E-02 3 56
45 Cytoskeleton remodeling_FAK signaling 2.127E-02 3 57
46 Immune response_Immunological synapse formation 2.329E-02 3 59
47 Development_EGFR signaling via PIP3 2.351E-02 2 23
48 Development_Thyroliberin signaling 2.540E-02 3 61
49 Development_Gastrin in cell growth and proliferation 2.650E-02 3 62
50 G-protein signaling_K-RAS regulation pathway 2.750E-02 2 25