Table 1 Pathways significantly enriched in the list of genes down-regulated by miR-125b and with a MRE in 3'UTR (source: GeneGO Metacore)
# | Maps | pValue | Ratio | |
|---|---|---|---|---|
1 | Immune response_CD28 signaling | 2.304E-04 | 5 | 54 |
2 | Development_EPO-induced PI3K/AKT pathway and Ca(2+) influx | 9.912E-04 | 4 | 43 |
3 | Neurophysiological process_Melatonin signaling | 9.912E-04 | 4 | 43 |
4 | Development_A2A receptor signaling | 9.912E-04 | 4 | 43 |
5 | Development_EPO-induced MAPK pathway | 1.178E-03 | 4 | 45 |
6 | Development_WNT5A signaling | 1.280E-03 | 4 | 46 |
7 | Neurophysiological process_NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons | 1.417E-03 | 5 | 80 |
8 | Nicotine signaling in dopaminergic neurons, Pt. 1 - cell body | 1.502E-03 | 4 | 48 |
9 | Development_A2B receptor: action via G-protein alpha s | 1.750E-03 | 4 | 50 |
10 | Signal transduction_PKA signaling | 1.884E-03 | 4 | 51 |
11 | Immune response_HSP60 and HSP70/ TLR signaling pathway | 2.329E-03 | 4 | 54 |
12 | Cell adhesion_Gap junctions | 3.608E-03 | 3 | 30 |
13 | Development_EGFR signaling pathway | 4.086E-03 | 4 | 63 |
14 | Oxidative stress_Role of ASK1 under oxidative stress | 5.161E-03 | 3 | 34 |
15 | Reproduction_GnRH signaling | 6.576E-03 | 4 | 72 |
16 | Development_Mu-type opioid receptor signaling | 7.062E-03 | 3 | 38 |
17 | Signal transduction_cAMP signaling | 7.062E-03 | 3 | 38 |
18 | Transcription_P53 signaling pathway | 7.594E-03 | 3 | 39 |
19 | Development_PACAP signaling in neural cells | 7.594E-03 | 3 | 39 |
20 | Apoptosis and survival_Lymphotoxin-beta receptor signaling | 9.328E-03 | 3 | 42 |
21 | Nicotine signaling in dopaminergic neurons, Pt. 2 - axon terminal | 9.953E-03 | 3 | 43 |
22 | Development_S1P1 signaling pathway | 1.060E-02 | 3 | 44 |
23 | Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling | 1.128E-02 | 3 | 45 |
24 | Transcription_Androgen Receptor nuclear signaling | 1.128E-02 | 3 | 45 |
25 | Development_Thrombopoietin-regulated cell processes | 1.128E-02 | 3 | 45 |
26 | Development_GDNF family signaling | 1.197E-02 | 3 | 46 |
27 | Neurophysiological process_Dopamine D2 receptor signaling in CNS | 1.269E-02 | 3 | 47 |
28 | Development_TGF-beta-dependent induction of EMT via MAPK | 1.269E-02 | 3 | 47 |
29 | Development_HGF signaling pathway | 1.269E-02 | 3 | 47 |
30 | Immune response_Histamine H1 receptor signaling in immune response | 1.344E-02 | 3 | 48 |
31 | Immune response_Lectin induced complement pathway | 1.421E-02 | 3 | 49 |
32 | Development_A3 receptor signaling | 1.421E-02 | 3 | 49 |
33 | Immune response_Histamine signaling in dendritic cells | 1.501E-02 | 3 | 50 |
34 | Mucin expression in CF via TLRs, EGFR signaling pathways | 1.501E-02 | 3 | 50 |
35 | Immune response_NFAT in immune response | 1.583E-02 | 3 | 51 |
36 | Development_IGF-1 receptor signaling | 1.667E-02 | 3 | 52 |
37 | Signal transduction_Activation of PKC via G-Protein coupled receptor | 1.667E-02 | 3 | 52 |
38 | Cell adhesion_ECM remodeling | 1.667E-02 | 3 | 52 |
39 | Immune response_Classical complement pathway | 1.667E-02 | 3 | 52 |
40 | Development_Endothelin-1/EDNRA signaling | 1.754E-02 | 3 | 53 |
41 | Membrane-bound ESR1: interaction with G-proteins signaling | 1.844E-02 | 3 | 54 |
42 | Development_FGFR signaling pathway | 1.844E-02 | 3 | 54 |
43 | Immune response_Fc epsilon RI pathway | 1.936E-02 | 3 | 55 |
44 | Regulation of lipid metabolism_Insulin regulation of glycogen metabolism | 2.030E-02 | 3 | 56 |
45 | Cytoskeleton remodeling_FAK signaling | 2.127E-02 | 3 | 57 |
46 | Immune response_Immunological synapse formation | 2.329E-02 | 3 | 59 |
47 | Development_EGFR signaling via PIP3 | 2.351E-02 | 2 | 23 |
48 | Development_Thyroliberin signaling | 2.540E-02 | 3 | 61 |
49 | Development_Gastrin in cell growth and proliferation | 2.650E-02 | 3 | 62 |
50 | G-protein signaling_K-RAS regulation pathway | 2.750E-02 | 2 | 25 |