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Figure 5 | Molecular Cancer

Figure 5

From: The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells

Figure 5

MM-121 in combination with trastuzumab significantly inhibits in vivo growth of tumor xenografts established from BT474-HR20 trastuzumab-resistant breast cancer cells. BT474-HR20 cells were s.c. injected into nude mice to establish tumor xenografts. The tumor-bearing mice (n = 5) received i.p. injections of PBS, trastuzumab, MM-121, or trastuzumab plus MM-121 as described in the Materials and Methods. After 6 treatments, the mice were euthanized at day 36 post injection of tumor cells, and all tumors were excised for histology and IHC analysis. A, The graphs show the tumor growth curves. Bars, SD. The combinations of MM-121 and trastuzumab significantly inhibited tumor growth as compared to control or single Ab treatment. B, Data show the representative tumors with hematoxylin and eosin (H&E) staining and IHC analysis of erbB2 and erbB3. The residual tumor cells obtained from combinatorial treatments retained similar expression levels of erbB2/erbB3 receptors on the cell membrane.

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Molecular Cancer

ISSN: 1476-4598