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Table 2 Fatty acids composition of whole HT29-dx cells

From: Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

 

CTRL

AA

DHA

EPA

C16:0

28.821 ± 2.333

28.352 ± 2.367

30.020 ± 3.349

29.630 ± 2.872

C16:1

10.532 ± 0.945

9.955 ± 1.003

9.027 ± 0.986

9.652 ± 0.905

C18:0

12.386 ± 1.082

11.401 ± 1.731

12.870 ± 2.455

12.229 ± 1.465

C18:1

30.878 ± 1.510

31.793 ± 2.214

30.288 ± 3.019

31.674 ± 2.552

C18:2

4.266 ± 0.792

2.563 ± 0.239

2.182 ± 0.368

3.025 ± 0.184

C18:3 ω -3

0.438 ± 0.068

0.955 ± 0.165**

0.514 ± 0.094

0.659 ± 0.036*

C18:3 ω -6

0.113 ± 0.011§

0.111 ± 0.013

0.147 ± 0.038

0.107 ± 0.009

C20:3

1.181 ± 0.209

0.828 ± 0.027

0.874 ± 0.107

0.895 ± 0.080

C20:4 (AA)

6.571 ± 1.563

9.813 ± 0.560*

3.182 ± 0.590*

3.694 ± 0.431*

C20:5 (EPA)

1.707 ± 0.425

0.812 ± 0.060

1.477 ± 0.227

5.852 ± 0.677**

C22:5

0.875 ± 0.080

0.823 ± 0.102

0.835 ± 0.166

1.101 ± 0.106

C22:6 (DHA)

2.280 ± 0.467

1.594 ± 0.274

8.345 ± 2.915*

1.481 ± 0.350

SFA a

41.208 ± 2.757

40.753 ± 3.507

42.890 ± 5.505

41.860 ± 4.067

MUFA b

41.410 ± 2.336

41.748 ± 3.196

39.555 ± 3.886

41.326 ± 3.443

ω -6

12.083 ± 2.310

13.315 ± 0.539

6.385 ± 0.735*

7.721 ± 0.309*

ω -3

5.300 ± 0.904

4.184 ± 0.315

11.171 ± 2.988*

9.094 ± 0.697**

ω -6/ ω -3

2.271 ± 0.198

3.208 ± 0.129**

0.679 ± 0.162**

0.863 ± 0.070**§

Fold increase c

 

2.782

5.862

7.028

  1. HT29-dx cells were left untreated (CTRL) or treated with AA, DHA, EPA (50 μM for 48 h).
  2. aSFA: saturated fatty acids; bMUFA: mono-unsaturated fatty acids.
  3. cFold increase: AA, DHA or EPA in treated cells versus AA, DHA or EPA in untreated cells, respectively.
  4. Data are presented as percentage of total fatty acids, mean ± SE (n = 3). Significance versus CTRL: *p < 0.05; **p < 0.01; versus the corresponding treatment in HT29 cells: § p < 0.05.