Figure 4
From: Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer
Ets-1 recruits Sx c -to maintain glutathione pool under oxidative stress. A) Glucose oxidase was used to induce oxidative stress in cultures, and successfully increased intracellular ROS levels in all cell lines. B) Under oxidative stress, PPG treatment resulted in decreased intracellular GSH levels. The amount of GSH was decreased by SAS in only ovarian cancer cells that express Ets-1 in abundance.