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Figure 1 | Molecular Cancer

Figure 1

From: Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis

Figure 1

Expression of CX3CR1 in tumor tissues. (A) Immunohistochemical analysis of CX3CR1 or macrophage marker CD68 expression in normal colon tissues and human colon carcinoma. Histopathological differentiation grade indicates well-, moderately- and poorly-differentiated. T indicates tumor invasion depth. N indicates lymph node metastasis. M indicates distant metastasis. (×200 magnification and Scale bars = 100 μm). Quantitative analysis of CX3CR1 expression in tumor sections at different histologic grade (well, moderate and poor), different tumor stages (I-IV) and with or without recurrence 3 years after operation (n = 5-10 samples per group, with 10 fields per samples). **, P<0.01. (B) Double-color immunofluorescence analyses of macrophage and CX3CR1 expression in tumors. Tumor tissues of metastasized foci in the liver were obtained from WT and CX3CR1−/− mice at 14 days after intrasplenic SL4 cells injection. The sections were immunostained with anti-F4/80 and anti-CX3CR1 antibodies. Three independent experiments were performed. (×400 magnification and Scale bars = 50 μm).

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