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Figure 2 | Molecular Cancer

Figure 2

From: Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis

Figure 2

CX3CR1 deficiency inhibits metastatic ability of colon cancer cells. (A) Gross examination of development of liver metastasized tumor of colon cancer 14 days after intrasplenic injection of SL4 cells in WT and CX3CR1−/− mice. SL4 cells (1 × 106) were injected into the spleen of WT and CX3CR1−/− mice. Mice were sacrificed at 14 days after tumor injection to determine the incidence of liver metastasis, the number of metastasized foci in the liver, tumor weight and total tumor area represented as% of liver tissue. Data are mean ± SEM for n = 10 mice **, P<0.01. (B) The analysis of micrometastasis was performed on paraffin-embedded sections with HE staining in metastasized foci after intrasplenic injection of SL4 cells in WT and CX3CR1−/− mice. T, tumor tissue; N, normal liver tissue. (×100 magnification and Scale bars = 100 μm). Data are mean ± SEM for n = 10 mice with 10 fields per animal. **, P<0.01.

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