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Figure 5 | Molecular Cancer

Figure 5

From: Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway

Figure 5

Elevated levels of PRLR mRNA in glioma cells treated with ES +  Tum. (A) Quantification of prolactin receptor mRNA expression revealed a 14-fold increase in G55 cells treated with CM containing ES + Tum when compared to G55 cells treated with CM from PA-WT cells. (B) Quantification of prolactin receptor mRNA expression in G55 cells treated with CM from PAE-WT, CM containing ES + Tum and cilengitide (CGT, 5 μg/ml) alone and in combinations. Bars represent the mean values ± SE from three independent experiments. (C) Immunofluorescence staining for PRLR in G55 cells after treatment with CM from PAE-WT and CM containing ES + Tum.

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