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Figure 6 | Molecular Cancer

Figure 6

From: Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway

Figure 6

PRLR overexpression in glioma cells in vitro . (A) Verification of PRLR-overexpression in the glioma cell line G55 using Western blot analysis and RT-PCR (left). Quantification of PRLR and PRL mRNA expression in stably PRLR-transfected (G55 PRLR) and mock-transfected ((G55 3.1(−)) G55 cells (right). (B) Effect of PRLR overexpression on cell growth in the presence or absence of PRL and the Jak-2 inhibitor AG-490. Bars represent the mean values ± SE (n = 5-6); ** on connecting lines indicates significant differences between respective groups (p < 0.005). (C) PRLR- and mock- (3.1(−)) transfected G55 cells were treated with CM from PAE-WT or CM containing ES + Tum with and without the Jak-2 inhibitor AG-490. Bars represent the mean values ± SE (n = 5-6); * on connecting lines indicates significant differences between respective groups (p < 0. 05).

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Molecular Cancer

ISSN: 1476-4598