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Figure 3 | Molecular Cancer

Figure 3

From: RETRACTED ARTICLE: α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway

Figure 3

α-santalol and positive control inhibited migration, invasion, and tube formation of HUVECs. (A) α-santalol inhibited HUVEC migration in wound healing assay. Cells were wounded with pipette and treated with vehicle or indicated concentrations of compounds. After 24 hours, the migrated cells were quantified by manual counting. (B) α-santalol inhibited HUVEC invasion in Transwell assay. A total of at 5 × 104 HUVECs were seeded in the top chamber and treated with vehicle or different concentrations of compounds. After 24 hours, the HUVECs that invaded through the membrane were stained and quantified. (C) α-santalol inhibited tube formation of HUVECs. After treated with vehicle or indicated concentrations of compounds for 10 hours, tubular structure in each group was quantified by manual counting. The percentage of inhibition was expressed using vehicle treated cells at 100%. Values are mean ± SEM (n = 6) of three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001 versus vehicle control.

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Molecular Cancer

ISSN: 1476-4598