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Figure 5 | Molecular Cancer

Figure 5

From: PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway

Figure 5

Effect of PinX1 on telomerase activity and telomere length in UCB cells. Telomerase activity was measured by TRAP assays and Southern blot analysis of telomeric terminal restriction fragments were used for determination of the telomere length. (A) Overexpression of PinX1 in EJ cells decreased telomerase activity and shortened telomere length. (B) Overexpression of PinX1 in T24 cells decreased telomerase activity and shortened telomere length. (C) RNAi-silencing of PinX1 in 5637 cells increased telomerase activity and elongated telomere length.

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Molecular Cancer

ISSN: 1476-4598