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Figure 5 | Molecular Cancer

Figure 5

From: Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1

Figure 5

TIPE2 decreased F-actin polymerization and expression of MMP9 and uPA via inhibiting Rac1 pathway. (A) After transfected with mock, TIPE2 and Mutant TIPE2 plasmids respectively, the microfilament in 7402 cell was stained with Tetramethylrhodamine (TRITC)-conjugated phalloidin and observed under laser confocal microscopy; (B) MMP9 and uPA levels in BEL-7402 and HepG2 were detected by Real time PCR; (C) The protein levels of MMP9 and uPA in BEL-7402 and HepG2 were detected by western blot. Data shown are representative of three independent experiments (n = 3). *P < 0.05; **P < 0.01.

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Molecular Cancer

ISSN: 1476-4598