Skip to main content
Figure 5 | Molecular Cancer

Figure 5

From: Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase

Figure 5

Effect of neutrophil elastase (NE) depletion on lung tumor promotion. (A) Total and lineage-specific leukocyte number in BALF of CC-LR mice and CC-LR-NEKO are shown (mean ± SE; * = P ≤ 0.05). (B) Lung surface tumor number of CC-LR and CC-LR-NEKO mice (mean ± SE; * = P ≤ 0.05 for CC-LR vs CC-LR-NEKO mice). (C) Histopathological appearance of lung tissue for CC-LR and CC-LR-NEKO (4× magnification, scale bar = 50 mm, applicable to all panels). (D) Level of IL-6 and TGF-β in BALF of CC-LR and CC-LR-NEKO mice (mean ± SE, * = P ≤ 0.05). (E) Quantitative analysis of Ki-67 positive staining in lung tissue of CC-LR and CC-LR-NEKO mice (mean ± SE; * = P ≤ 0.05). (F) Representative photomicrographs of Ki-67 positive cells in lung tissue of CC-LR and CC-LR-NEKO mice (40× magnification, scale bar = 50 mm, applicable to all panels). (G) Quantitative analysis of CD31 positive staining in lung tissue of CC-LR and CC-LR-NEKO mice (mean ± SE; * = P ≤ 0.05). (H) Representative photomicrographs of CD31 positive cells in lung tissue of CC-LR and CC-LR-NEKO mice (20× magnification, scale bar = 50 mm, applicable to all panels). (I) Expression level of the VEGF in BALF of CC-LR and CC-LR-NEKO mice (mean ± SE, * = P ≤ 0.05). (J) Representative photomicrograph of VEGF positive cells in lung tissue of CC-LR and CC-LR-NEKO mice (20× magnification, scale bar = 50 mm, applicable to all panels). (K) Quantitative analysis of cleaved-caspase-3 positive staining in lung tissue of CC-LR and CC-LR-NEKO mice (mean ± SE; *P ≤ 0.05). (L) Representative photomicrographs of cleaved-caspase-3 positive cells in lung tissue of CC-LR and CC-LR-NEKO mice (20× magnification, scale bar = 50 mm, applicable to all panels).

Back to article page