Suppression of PMP22 enhances proliferation. MCF-7 and MDA-MB-231 cells were transiently transfected with siRNA targeting PMP22 (A-B) or PMP22 and G3BP1 (C-D) prior to [3H]-thymidine incubation (A and C-D) or qPCR analysis (B). Basal PMP22 expression levels were analysed in MCF-7 and MDA-MB-231 cells using qPCR (E). Data (mean ± SEM, n = 3) are expressed as CPM relative to control. qPCR data (mean ± SEM, n = 3) of PMP22 expression were normalized to three house-keeping genes SDHA, YWHAZ and UBC and related to control sample. * < 0.05, ** < 0.01, *** < 0,001, according to ANOVA followed by Duncan’s multiple range test.