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Figure 5 | Molecular Cancer

Figure 5

From: Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer

Figure 5

ABT-737 and chloroquine combination therapy alters the expression levels of apoptotic regulatory factors in SCLC. The cell lines H82, H209 and H345 were treated with DMSO (control), ABT-737, CQ, and combinations of the two drugs for 72 hours before protein lysates were isolated. Doses of ABT-737 and CQ that were below or approximating the cell line specific IC50 values for each agent were chosen. Beta-actin is shown as an internal loading control and cleaved-PARP is shown for relative induction of apoptosis. NOXA was undetectable in H209 and Bcl-2 was barely detectable in H82.

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