Figure 1
From: Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer
miR-124 is downregulated in breast cancer cell lines and human breast cancer specimens, and the reduced expression is associated with advanced clinical stage and positive lymph node metastasis in breast cancer patients. A, Expression of miR-124 in 7 breast cancer cell lines and 2 normal breast epithelial cell lines; miR-124 expression was determined by qRT-PCR and normalized to 5S rRNA. B, Expression of miR-124 in 78 cases of human breast cancer and 40 corresponding normal adjacent tissues. C, Expression levels of miR-124 are associated with lymph node metastasis of breast cancer (P = 0.0004). D, Expression levels of miR-124 in different clinical stages of breast cancer patients (P = 0.0004). Statistical analysis is performed using the paired t-test (B) and the Student t-test (C and D). Data are shown as the mean ± SEM. NATs: normal adjacent tissues.