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Figure 3 | Molecular Cancer

Figure 3

From: Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer

Figure 3

MiR-124 directly regulates FLOT1 by binding to the FLOT1 3′-UTR. A, Putative miR-124 binding site in the 3′-UTR region of FLOT1 and interspecies conservation of seed matching sequences (gray box). B, Diagram of FLOT1 3′-UTR contained reporter constructs. C, Luciferase reporter assays in MDA-MB-231 cells. Co-transfected of wt/mut 3′-UTR with miRNAs as indicated. D, Expression levels of FLOT1 are tested after miR-124 transfected at 50 nM in MDA-MB-231 and T47D by western blot assay. *, P < 0.05 compared with control.

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