Table 2 Biological functions and roles in breast cancer of proteins differentially expressed in CD133 low and CD133 high cells
Proteins | Main function/Biological process | Known roles in breast cancer | CD133highversus CD133low |
|---|---|---|---|
Tm4 | Actin-binding protein/Cell motility | Metastasis (32), Chemotherapy resistance (34) | Up |
14-3-3 ϵ | Protein binding/Cell cycle | Chemotherapy resistance (34) | Down |
14-3-3 σ | Protein binding/Cell cycle, apoptosis | Tumor suppression (35) | Down |
14-3-3 β/α | Protein binding/Cell cycle, apoptosis | Chemotherapy resistance (34) | Down |
TCP-1-α | Molecular chaperone/Cell motility | Metastasis (36) | Down |
LEI | Protease inhibitor/Protein metabolism | Cell migration and invasiveness suppression (37) | Down |
AdoHcyase | Hydrolase/Protein metabolism | Oncogenic (38) | Up |
eIF-2A | Initiation factor/Protein metabolism | Protein biosynthesis (39) | Down |
PP2A- β | Protein phosphatase/Apoptosis | Tumor suppression (40) | Down |
eIF3β | Initiation factor/Protein metabolism | Oncogenic (41) | Up |
DDAH-1 | Hydrolase/Metabolic pathways | Unknown | Down |
PPase | Pyrophosphate hydrolysis/Metabolic pathways | Chemotherapy resistance (34) | Down |
Annexin A3 | Phospholipase A2 inhibitor/Metabolic pathways | Chemotherapy resistance (34) | Down |
CapZ β | Actin capping/Cell motility | Chemotherapy resistance (34) | Down |
PA28γ | Protein binding/Cell cycle, apoptosis | Unknown | Down |