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Table 2 Biological functions and roles in breast cancer of proteins differentially expressed in CD133 low and CD133 high cells

From: In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness

Proteins Main function/Biological process Known roles in breast cancer CD133highversus CD133low
Tm4 Actin-binding protein/Cell motility Metastasis (32), Chemotherapy resistance (34) Up
14-3-3 ϵ Protein binding/Cell cycle Chemotherapy resistance (34) Down
14-3-3 σ Protein binding/Cell cycle, apoptosis Tumor suppression (35) Down
14-3-3 β/α Protein binding/Cell cycle, apoptosis Chemotherapy resistance (34) Down
TCP-1-α Molecular chaperone/Cell motility Metastasis (36) Down
LEI Protease inhibitor/Protein metabolism Cell migration and invasiveness suppression (37) Down
AdoHcyase Hydrolase/Protein metabolism Oncogenic (38) Up
eIF-2A Initiation factor/Protein metabolism Protein biosynthesis (39) Down
PP2A- β Protein phosphatase/Apoptosis Tumor suppression (40) Down
eIF3β Initiation factor/Protein metabolism Oncogenic (41) Up
DDAH-1 Hydrolase/Metabolic pathways Unknown Down
PPase Pyrophosphate hydrolysis/Metabolic pathways Chemotherapy resistance (34) Down
Annexin A3 Phospholipase A2 inhibitor/Metabolic pathways Chemotherapy resistance (34) Down
CapZ β Actin capping/Cell motility Chemotherapy resistance (34) Down
PA28γ Protein binding/Cell cycle, apoptosis Unknown Down