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Figure 6 | Molecular Cancer

Figure 6

From: Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors

Figure 6

Down regulation of AnxA6 sensitizes invasive breast cancer cells to EGFR-targeted TKIs. A) Control (BT-EV) and AnxA6-depleted (A6sh5) BT-549 cells were cultured as above and treated with the indicated concentrations of the indicated EGFR TKIs for 72 h. Cell viability/proliferation was determined using PrestoBlue cell viability assay. Experiments were performed in triplicate and repeated at least three times. Points represent mean viability ± S.E.M relative to DMSO control treated cells. * p < 0.05, *** p < 0.0001 versus respective controls. B) AnxA6-depleted MDA-MB-231 and BT-549 as well as AnxA6-over expressing HCC1806 cells with their respective controls were treated with 5 μM of the indicated EGFR-TKI or DMSO control. Cell viability was determined as above. Bars represent mean viability ± S.E.M relative to DMSO control treated cells. * p < 0.05 versus respective controls.

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