Immunohistochemical staining for PDPN in IDC of the pancreas. (A-a) Pancreatic IDCs consisted of cancer cells and stromal cells such as CAFs. (A-b) CAFs around the cancer cells were positive for PDPN. (A-c) In the normal main pancreatic duct, stromal cells were rarely positive for PDPN. The arrow indicates lymphatic vessels as a positive control. (B, C) Stromal PDPN expression was associated with a worse overall survival rate (B) and disease-free survival rate (C) by Kaplan-Meier survival analysis.